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James D Hoeschele Selected Research

Oxaliplatin (Eloxatin)

6/2022Improvement of Kiteplatin Efficacy by a Benzoato Pt(IV) Prodrug Suitable for Oral Administration.
6/2021New Oxaliplatin-Pyrophosphato Analogs with Improved In Vitro Cytotoxicity.
3/2020Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance.
1/2020Synthesis, antiproliferative activity in cancer cells and DNA interaction studies of [Pt(cis-1,3-diaminocycloalkane)Cl2] analogs.
10/2019A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring.
7/2018Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions.
5/2018Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands.
1/2017Cisplatin, Oxaliplatin, and Kiteplatin Subcellular Effects Compared in a Plant Model.
8/2016Hydroxyapatite nanocrystals as a smart, pH sensitive, delivery system for kiteplatin.
8/2016Encapsulation of lipophilic kiteplatin Pt(iv) prodrugs in PLGA-PEG micelles.
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James D Hoeschele Research Topics

Disease

13Neoplasms (Cancer)
04/2023 - 08/2012
5Colonic Neoplasms (Colon Cancer)
01/2017 - 08/2012
4Colorectal Neoplasms (Colorectal Cancer)
06/2022 - 08/2012
1Urinary Bladder Neoplasms (Bladder Cancer)
04/2023
1Ovarian Neoplasms (Ovarian Cancer)
04/2023
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2023
1Lewis Lung Carcinoma
06/2022
1Necrosis
06/2021
1Uterine Cervical Neoplasms (Cancer of the Cervix)
03/2020
1Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2020
1Carcinoma (Carcinomatosis)
10/2019
1Rectal Neoplasms (Rectal Cancer)
01/2016
1Bites and Stings (Sting)
02/2015
1Brain Neoplasms (Brain Tumor)
06/2014
1Glioma (Gliomas)
06/2014

Drug/Important Bio-Agent (IBA)

14Oxaliplatin (Eloxatin)FDA LinkGeneric
06/2022 - 08/2012
9Cisplatin (Platino)FDA LinkGeneric
04/2023 - 08/2012
8platinum(II)(1,4- diazacycloheptane)dichlorideIBA
06/2022 - 09/2014
8LigandsIBA
06/2022 - 08/2012
6PlatinumIBA
11/2021 - 07/2014
31,2-cyclohexanediamine (dach)IBA
06/2022 - 08/2012
3Benzoates (Benzoate)IBA
06/2022 - 01/2016
3Antineoplastic Agents (Antineoplastics)IBA
09/2014 - 08/2012
2DiaminesIBA
06/2022 - 08/2016
2ProdrugsIBA
06/2022 - 03/2020
11,4-diaminocyclohexaneIBA
06/2021
1cyclohexeneIBA
03/2020
1OxalatesIBA
01/2020
1Glutathione (Reduced Glutathione)IBA
01/2020
1DNA (Deoxyribonucleic Acid)IBA
01/2020
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
05/2018
1NitrogenIBA
02/2015
1Protons (Proton)IBA
02/2015
1AminesIBA
09/2014
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
07/2014
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
06/2014
1trichloronitritodiammineplatinum(IV)IBA
06/2014
1WP1066IBA
06/2014
1piperidineIBA
06/2014

Therapy/Procedure

2Therapeutics
04/2023 - 06/2014
1Intraperitoneal Injections
06/2022
1Oral Administration
06/2022
1Drug Therapy (Chemotherapy)
08/2012